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Marbofloxacin Might Prevent Transport-Associated Fever for Racehorses

19 Jun 2015 3:46 PM | Deleted user

With the globalization of horse racing, racehorses are frequently shipped long-distances via airplane or horse trailer. Transport-associated fever is a common and potentially serious issue that can disrupt training and racing schedules or indicate an infection, potentially leading to pneumonia or pleuropneumonia. So, veterinarians, researchers, and owners alike are in search of ways to reduce a horse's likelihood of developing transport-associated fever.

Recently, Yoshiro Endo, DVM, of the Japan Racing Association’s Hidaka Training and Research Center, in Hokkaido; Seiji Hobo, DVM, PhD, of Kagoshima University; and colleagues investigated the effects of administering 2 mg/kg of marbofloxacin (MRFX) to healthy Thoroughbreds prior to long-distance transport. Another group of horses received saline and served as controls.

The team determined that MRFX was significantly more effective than saline in protecting against transport-associated fever.

Still, this new quinolone (synthetic broad-spectrum antibacterial) antibiotic isn't the be-all and end-all of transport-associated fever prevention. Antibiotic use raises concerns about the potential for resistant bacteria and, as a result, the Japanese Ministry of Agriculture, Forestry and Fisheries restricts MRFX use. Endo said the rule targets cattle, but still applies to horses, as well; “We think that this rule is unnecessary,” he added.

To reduce the chances of resistant bacteria development, Endo recommended the following guidelines for using MRFX in association with long-distance transport: “MRFX should only be used at transportation and only for long periods of transportation, projected to exceed 20 hours,” he said. Additionally, only use it for animals that have developed shipping fever previously or have an elevated risk of developing shipping fever (e.g., horses with a history of laryngoplasty [tie-back surgery] or pneumonia). Finally, only use antibiotics after you've carried out all other steps for preventing fever, such as improving vehicle ventilation.

Based on these study results, Endo, et al. believe administering MRFX (along with interferon-α, an immunostimulant) to healthy Thoroughbreds prior to transportation is worth further consideration for preventing transport-associated fever

Preventing fever helps owners maintain their horses' training and racing schedules while potentially minimizing the physical toll associated with long-distance transportation.

The study, “Effects of pre-shipping marbofloxacin administration on fever and blood properties in health Thoroughbreds transported a long distance,” was published in the Journal of Veterinary Medical Science.

Full Story here: http://www.thehorse.com/articles/35869/marbofloxacin-might-prevent-transport-associated-fever

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